Search results for "ADHD symptoms"
showing 10 items of 12 documents
A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts
2016
OBJECTIVE: The aims of this study were to elucidate the influence of common genetic variants on childhood attention-deficit/hyperactivity disorder (ADHD) symptoms, to identify genetic variants that explain its high heritability, and to investigate the genetic overlap of ADHD symptom scores with ADHD diagnosis. METHOD: Within the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, genome-wide single nucleotide polymorphisms (SNPs) and ADHD symptom scores were available for 17,666 children (<13 years of age) from nine population-based cohorts. SNP-based heritability was estimated in data from the three largest cohorts. Meta-analysis based on genome-wide association (GWA) analyses w…
INFLUENCIA DE FACTORES FAMILIARES Y PERSONALES EN LA EVOLUCIÓN NEGATIVA DEL TDAH
2016
Abstract.INFLUENCE OF PERSONAL AND FAMILY FACTORS ON THE NEGATIVE COURSE OF ADHDObjective. To study the effect of the cumulative adversity on the course of ADHD symptoms, associated problems and dysfunctionality of ADHD children. Method. 61 families of children with a clinical diagnosis of ADHD combined subtype were evaluated on two different times (Time I: mean age = 8.7; Time II: mean age = 11). We developed a personal risk index (high levels of ADHD symptoms, high number of associated problems, presence of oppositionism, stressful child characteristics and family history of ADHD), a family risk index (presence of mothers’ psychopathology, high parental stress and dysfunctional discipline…
ADHD Symptoms and peer problems: Mediation of executive function and theory of mind
2017
Background: The social maladjustment suffered by many children with attention defi cit hyperactivity disorder (ADHD) is maintained over time, increasing the risk of subsequent adverse outcomes. The objectives of the study were to explore the mechanisms that operate between ADHD symptoms and social problems with peers, considering the mediation of FE and ToM. Method: 35 children with ADHD and 37 with typical development matched in age and IQ were compared. Parents assessed ToM skills and relationships with peers, and teachers provided EF ratings. Results: The analyses showed statistically signifi cant indirect mediation effects of EF in the relationship between ADHD symptoms and problems in …
Psychometrische Güte der Selbst- und Fremdbeurteilungsinstrumente ADHS-SB und Wender-Reimherr-Interview bei Senioren mit Aufmerksamkeitsdefizit-/Hype…
2016
Zusammenfassung Ziel der Studie und Methodik Die Anwendbarkeit der etablierten ADHS-Verfahren für Erwachsene, ADHS-SB und Wender-Reimherr-Interview, im Senium wurde an einer Stichprobe von 324 Personen im Alter zwischen 60 und 99 Jahren überprüft. Ergebnisse Die beiden Verfahren weisen für den Einsatz bei SeniorInnen eine geringere psychometrische Güte auf im Vergleich zur Anwendung bei Erwachsenen im jungen und mittleren Lebensalter. Es zeigt sich eine hohe Korrelation beider Verfahren mit der klinischen Beurteilung der Experten bei Personen im Seniorenalter. Schlussfolgerung Als Ergänzung zur ausführlichen klinischen Exploration können die ADHS-SB und das WRI auch im Senium als valide Dia…
Correlations Between Clinical Trial Outcomes Based on Symptoms, Functional Impairments, and Quality of Life in Children and Adolescents With ADHD
2017
Objective: To assess relationships between treatment-associated changes in measures of ADHD symptoms, functional impairments, and health-related quality of life in children and adolescents with ADHD. Method: Pearson correlation coefficients were calculated post hoc for changes from baseline to endpoint in outcomes of one randomized, placebo- and active-controlled trial of lisdexamfetamine (osmotic-release methylphenidate reference) and one of guanfacine extended-release (atomoxetine reference). Results: Changes in ADHD Rating Scale IV (ADHD-RS-IV) total score generally correlated moderately with changes in Child Health and Illness Profile−Child Edition: Parent Report Form (CHIP-CE:PRF) Ach…
Assessment of Susceptibility Risk Factors for ADHD in Imaging Genetic Studies
2019
Objective: ADHD consists of a count of symptoms that often presents heterogeneity due to overdispersion and excess of zeros. Statistical inference is usually based on a dichotomous outcome that is underpowered. The main goal of this study was to determine a suited probability distribution to analyze ADHD symptoms in Imaging Genetic studies. Method: We used two independent population samples of children to evaluate the consistency of the standard probability distributions based on count data for describing ADHD symptoms. Results: We showed that the zero-inflated negative binomial (ZINB) distribution provided the best power for modeling ADHD symptoms. ZINB reveals a genetic variant, rs273342…
Masculinization in Parents of Offspring With Autism Spectrum Disorders Could Be Involved in Comorbid ADHD Symptoms
2017
OBJECTIVE: People with autism spectrum disorders (ASD) often have comorbid ADHD symptoms. ASD and ADHD are both associated with high intrauterine testosterone (T) levels. This study aims to investigate whether masculinization predicts inattention symptoms in parents, and in their ASD-affected offspring.METHOD: The sample consisted of 32 parents with ASD-affected children (13 male, 19 female) and 32 offspring individuals (28 male, 4 female). Masculinization of parents was measured by 2D:4D finger ratio, and current T levels. Inattention in both parents and in their offspring was measured with behavior questionnaires.RESULTS: The results indicated that masculinized 2D:4D explains inattentive …
Analysis of Personal and Family Factors in the Persistence of Attention Deficit Hyperactivity Disorder: Results of a Prospective Follow-Up Study in C…
2015
Objectives To study the course of ADHD during childhood and analyze possible personal and family predictor variables of the results. Method Sixty-one children with ADHD who were between 6 and 12 years old at the baseline assessment were evaluated 30 months later (mean age at baseline: 8.70 ± 1.97; mean age at follow-up: 10.98 ± 2.19). Status of ADHD in follow-up was identified as persistent (met DSM-IV-TR criteria according to parents’ and teachers’ ratings), contextually persistent (met ADHD criteria according to one informant, and there was functional impairment) and remitted ADHD (with subthreshold clinical symptomatology). Associated psychological disorders of the three groups were anal…
Evidence for shared environmental contributions to attention-deficit/hyperactivity traits. A twin study
2019
Background and objectives: Behavior-genetic analyses have shown that measurements of inattention and hyperactivity-impulsivity are genetically-influenced. In view of limited studies on ADHD (Attention deficit hyperactivity disorder) in Spanish samples, this study aims to explore the genetic architecture of ADHD symptoms; inattention and hyperactivity-impulsivity in a Spanish twin schoolchildren sample. Methods: Participants were 258 pairs of adolescent Spanish twins. Symptoms of ADHD, inattention and hyperactivity-impulsivity were assessed by means of a sub-scale of the Strengths and Difficulties Questionnaire. Univariate twin models, according to sex, were run to assess the heritability of…
Prospective relationships of ADHD symptoms with developing substance use in a population-derived sample
2011
BackgroundClinically ascertained reports suggest that boys and girls with attention deficit hyperactivity disorder (ADHD) may differ from each other in their vulnerability to substance use problems.MethodA total of 1545 Finnish adolescents were assessed for DSM-IV-based ADHD symptoms by their parents and classroom teachers using standardized rating scales at age 11–12 years. At age 14, substance use disorders and psychiatric co-morbidity were assessed with the Semi-Structured Assessment for the Genetics of Alcoholism, providing DSM-III-R/DSM-IV diagnoses for Axis I disorders. At age 17.5, substance use was assessed by multi-item questionnaire.ResultsAlthough baseline ADHD symptoms were less…